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1996-02-27
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Document 0169
DOCN M9630169
TI Fatty acids and plasma antioxidants in HIV-positive patients:
correlation with nutritional and immunological status.
DT 9603
AU Constans J; Peuchant E; Pellegrin JL; Sergeant C; Hamon C; Dubourg L;
Thomas MJ; Simonoff M; Pellegrin I; Brossard G; et al; Service de
Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre,
Bordeaux, France.
SO Clin Biochem. 1995 Aug;28(4):421-6. Unique Identifier : AIDSLINE
MED/96129102
AB OBJECTIVE: To investigate red blood cell (RBC) and plasma fatty acids
(FA) in HIV-positive patients in relation to oxidative stress and
nutritional or immunological status. DESIGN AND METHODS: FA, plasma
selenium, vitamins A and E were measured in 95 patients divided into
four groups according to CD4 cells. RESULTS: Poly- and di-unsaturated FA
(PUFA, DUFA) decreased and saturated FA (SFA) increased in RBC in the
patients below 400/mm3 and in plasma in the patients below 50/mm3. RBC
SFA correlated to CD4 cells, PUFA to MDA. Unlike vitamin E, plasma
vitamin A and selenium decreased in most groups. Plasma SFA and MUFA
correlated negatively to selenium and PUFA and DUFA to vitamin E. No
correlation was found between PUFA and nutritional markers. CONCLUSION:
FA seem to be modified during HIV infection by oxidative stress and
disease evolution, but not by denutrition.
DE Adult Antigens, CD4/ANALYSIS Antigens, CD8/ANALYSIS
Antioxidants/*ANALYSIS Case-Control Studies Erythrocyte
Membrane/CHEMISTRY Fatty Acids/*BLOOD Female Human HIV
Seropositivity/BLOOD/*IMMUNOLOGY *Immunocompetence Male
Malondialdehyde/ANALYSIS Middle Age *Nutritional Status Oxidative
Stress Selenium/BLOOD Vitamin A/BLOOD Vitamin E/BLOOD CLINICAL TRIAL
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).